Redesign reflects new dimensions

Tailoring new enzyme functions by rational redesign.

Site-directed mutagenesis is still a very efficient strategy to elaborate improved enzymes. Recently, advances have been made in developing rational strategies aimed at reshaping enzyme specificities and mechanisms, and at engineering biocatalysts through molecular assembling. These knowledge-based studies greatly benefit from the most recent computational analyses of enzyme structures and func...

New impact factor reflects increased quality.

Infinitely large new dimensions

We construct intersecting brane configurations in anit-de Sitter (AdS) space which localize gravity to the intersection region, generalizing the trapping of gravity to any number n of infinite extra dimensions. Since the 4D Planck scale M(Pl) is determined by the fundamental Planck scale M(*) and the AdS radius L via the familiar relation M(2)(Pl) approximately M(2+n)(*)L(n), we get two kinds o...

New Dimensions of LIght

My research expands the design space of computational imaging by (i) using new sensors to sample and probe multiple dimensions of light in a scene, and (ii) building software-defined image sensors with custom on-chip signal processing. This enhanced design space will lead to the next generation of intelligent cameras that help drones identify obstacles in flight with minimal power, digitally ca...

Automated Redesign with the General Redesign Engine

Given a system design (SD), a key task is to optimize this design to reduce the probability of catastrophic failures. We consider the task of redesigning an SD to minimize the probability of particular faults by introducing components selected from a component library. We have implemented a General Redesign Engine (GRE), which uses model-based reasoning techniques and Boolean functional synthes...